STX 64

Name	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
Synonyms	STX 64 BN 83495 Irosustat COUMATE. Irosustat. DSLPMJSGSBLWRE-UHFFFAOYSA-N 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
CAS	288628-05-7
EINECS	604-604-1

Molecular Formula	C14H15NO5S
Molar Mass	309.34
Density	1.48±0.1 g/cm3(Predicted)
Melting Point	170.1-173.4 °C
Boling Point	544.1±60.0 °C(Predicted)
Solubility	DMSO : 150 mg/mL (484.90 mM)
Appearance	white powder
pKa	8.26±0.70(Predicted)
Storage Condition	2-8°C
In vitro study	Irosustat (667 COUMATE) is a potent steroid sulfatase inhibitor, with an IC 50 of 8 nM. Irosustat (667 COUMATE) inhibits steroid sulphatase (STS) activity in MCF-7 cells with an IC 50 of 0.2 nM, but has no effect on the morphology or proliferation of MCF-7 cells at 10 μM.
In vivo study	Irosustat potently inhibits rat liver, with inhibition of >90% when at a 1 mg/kg concentration. Irosustat (2 mg/kg, p.o. for 5 d) blocks the uterine growth stimulated by oestrone sulfate (E1S) in ovariectomized rats. In addition, Irosustat (2, 10 mg/kg, p.o.) plus E1S dose-dependently decreases the growth of NMU-induced mammary tumors in ovariectomized rats. Irosustat (667 COUMATE; 10 mg/kg, p.o.) shows 97.9 ± 0.06% inhibition on steroid sulphatase (STS) activity in rat liver.